Before I went European sovereign for my own personal stack I used Cloudflare for hosting static and somewhat dynamic websites and it has become really nice the later years. There is almost no mention of "regions" in Cloudflare. Your content and code runs globally by default. With traditional clouds you need to think about how you distribute your application. At least that is my experience. Maybe they provide global CDN for global distribution of static content. But serverless containers and databases more or less run in a single region by default. And if you wish to distribute stuff it is on you to plan the architecture behind that.

Now stuff like Cloudflare D1, the distributed SQLite based database, have its limitations. Writes are directed to a specific datacenter/region behind the scenes, so some regions might get slower writes. But this is basically something that happens behind the scenes and just works. You need to think about where your primary base of customers live when you create the database, after that you don't think about regions. R2 (S3 compatible storage) just works globally as well.

A lot of what Cloudflare offers now feels like magic in a good way. I realize they don't have everything AWS, Google Cloud and Azure have. But they have enough that you can build serious systems on top of their infrastructure. They are no longer just a CDN/proxy provider. And their offering is seriously cheap.