If you have a very inefficient backend (maybe legacy project?), you have massive amount of traffic (say 100K req/s or above) or you really must have sub-500ms latency absolutely everywhere in the world, then it might make sense to slap a CDN (or similar) on top of that.
In pretty much any case outside of that, it makes no sense to waste the time, money or effort on CDNs. But, all the CDN companies seemingly have convinced half the internet that you absolutely must use a CDN, otherwise you'll get hacked/broke/killed/sent to the moon, and they've been successful with this campaign too seemingly.