Just given dark matter and energy, things the standard model doesn't answer, and our evolving tools (e.g. Grace telescope, etc.).
This means that today to make new discoveries we tend to have to invest huge sums of money and build experiments that we'll increasingly struggle to scale significantly beyond. For example, maybe humans could just about build something 10x the size of the LHC if we really wanted, but 100x seems near-impossible. Maybe we can build slightly larger telescopes, but again, this is becoming harder due to the scale we're already working at.
So while I agree there's probably lots of physics out there to discover, the physics we humans are actually likely to be able to discover is rapidly diminishing. And the physics which is likely to revolutionise our daily lives is presumably even smaller more due to scale and energy levels where mysteries remain.
But ultimately who knows, this is just my opinion – an opinion I'm being downvoted for because apparently HN discussions these days are a place for us circlejerk around the consensus view rather than discuss differences in opinion.