One such situation:
A particularly competent "scripter" writes automation programs for the most complicated content in the game. As such, they sell at a premium. It makes you and him considerable money for many months. Eventually, the community starts to develop a free version of this same automation program. You are now in a situation where you've likely built your business around the expectation of revenue from this one "scripter" and his/her products. Maybe you've even given them a more favorable revenue share model.
Another issue that can pop up from this, especially in lower pop games, is that it's very obvious from a statistics point of view. The game developer will easily take notice if the hardest content in the game is suddenly being done many times per day by players who have never showed an affinity for such content. This in turn increases ban numbers which hurts your product's reputation.
All of this is to say: Having thousands of hours in the game you are working on is a massive benefit at every turn. It is best to work on games you genuinely enjoy.