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Give Reaper a try, it works very well on linux and you can even use VSTs.

Sadly a lot of VSTs are Windows and Mac only too due to shitty DRM. :-(

True. On the other hand, there are top quality developers like u-he Urs Heckmann that provide native linux support.

AudioThing, TAL and Modartt have Linux versions as well. Korneff Audio is moving in that direction, but not everything is ported over yet.