If you are a general aviation goober like me, flying a 1960's propeller airplane, sure, that is true.

However, in a modern commercial aircraft, all position sources including VOR-DMEs, GPS, and IRS are cross-compared by the flight management system and turned into a latitude, longitude, and circular error of probability. There is no TO/FROM flag to worry about in a 777, and no reverse sensing on the back side of a localizer approach.