Any stack has its own warts.
The only benefit is familiarity and data science. That’s literally it. No one in this thread has stated any benefit Python brings to the table on top of other popular web application languages.
I guess ruby is a worse choice.
Django is fast but has become much less relevant in the age of AI. The issue with Django is you hit issues very early. Within 2 to 3 years of using Django the warts of using Django become apparent. Django is mostly a good tool for the first year, but if the tool survives beyond that, Django becomes more of a liability.
You get 80 percent of the convenience of Django with just popular nodejs libs like prisma, zod and express. Once you add in LLS it’s 100 percent.
I personally avoid to touch anything that is nodejs related because I do not trust its ecosystem (npms).