Absolutely.

Like I agree with most everything he says and I like to optimise my own software, but for my day to day jobs and contracts it's simply not feasible.

That level of performance and rigor is not what is demanded nor paid or appreciated.

E.g. in Enterprise circles it's still OOP from top to bottom.

Mixed with a tad more functional style due to varying adoption of that paradigm in the languages used by enterprise.

But low level optimizations are not interesting to these customers at all, even though they could help them with some problems.