The best thing you could take away from this lecture is something a reasonable person should take away from the original "root of all evil" saying anyway. Measure. Measure. Measure. If you aren't measuring that's not optimization it's masturbation.
Ironically in the process of measuring for a third time yesterday I tripped a bug in Bill's language for which I opened an issue. This is not the goal of measuring three times but merely a happy accident.
Along the way Casey discovers (?) that Structured Programming means just what we today call programming†, that software was a lot smaller in the days when 4096 bytes of RAM was a good entry level option and that loads of these famous people from 1970s computer science knew each other.
† And knowing about this is one reason the Structured Concurrency people want that everywhere. Very possibly there's a future where it seems silly that people once wrote programs which did not use structured concurrency.