> Despite considerable improvements in side-effect profiles, antidepressants continue to be associated with a significant burden of side effects that affect, treatment adherence and quality of life. Hu et al1 studied 401 patients with depression who had recently been prescribed an SSRI, and found that, after 75 to 105 days of treatment, 86% of patients reported at least, one side effect, and 55% experienced one or more bothersome side effects.