When I was in college a doctor told me a trick. I did the trick and I never got a hangover again.

The trick: put a 3-liter (that's right, three liters) plastic bottle of water on your bed pillow before you go out drinking. When you arrive back home, drink all of it. (You place it on your pillow so that it will remind you, in case you forget.) There's a time element involved, because you can't exactly drink three liters of water in a minute. But take the time and drink the water.

I never got a hangover again. I did feel a little seasick once or twice, in the morning, after a particularly hard night out. But no pounding headache, etc.