Though as for games that use SF (but not 1:1) Watch Dogs 2 is a pretty good proxy, though my favorite video game interpretation of San Francisco is from GTA San Andreas (San Fierro)
We recently used Watch Dogs Legion to prep for a trip to London to get more familiar with the city. Set the game on peaceful mode and just walked around and did virtual sight-seeing instead of playing missions. It's a surprisingly good recreation of the city, and we really appreciated getting some familiarity with the place before we visited.
It wasn't perfect, but it did help a little. The streets are way narrower, and the traffic is much worse, but muscle memory to stay on the left side of the road was nice.