Does it matter if you are living in a simulation, or not?
Imagine if it is proven.
How the people will react? That could really make you want to rebel, couldn't it?
Or falling in depression. Or even giving you the curiosity to understand WY this simulation is made for?
No, that is different. I am talking if it matters before Morpheus shows up with his pills (btw, there's also the option that you take no pill from a complete stranger, neither a blue nor a red one).
And if its proven, it depends on how abstract and theoretical it all is. Anyway, Permutation City [0] by Greg Egan might be a nice read for you.