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Comment by miki123211 | Hacker News Reader

I swear, Semaglutide is reverse Asbestos.

It's something we found and started using to one specific problem, but it later turned out that it has lots of other, extremely wide-ranging consequences. Except that in this case, these consequences are positive.

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Semaglutide reduces appetite. Who could have known that eating less will have positive effects?

Maybe we should try consuming less in general and see what the effects are. Is there a semaglutide for my shopping habits? Maybe ban ads?

GLP-1 does a lot more than just stomach signaling. It shrinks visceral fat, it's been shown to clear liver fat, and it actually increases mitochondrial efficiency similar to if you were to do endurance work/cardio. There's a lot going on with it. That's kind of what the parent is talking about, all these second-order effects that were not obvious. There is also evidence of down-regulated mTOR signaling and epigenetic protection. And these aren't all just bullshit, big pharma funded studies either.

> It shrinks visceral fat, it's been shown to clear liver fat

The brain is 60% fat, so I'm not running to the pharmacy yet.

Myelin and membranes aren’t triglyceride stores. There’s no lipolytic pathway that strips a neuron’s membrane the way a caloric deficit empties an adipocyte.

Calling it now, the downside is the effects are most apparent on higher dosages, but you cant take higher dosages forever. Eventually you run out of body fat, have go reduce the dose, and the benefits dither.

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