With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.
Semaglutide and glp1s resensitize it which is why they have these effects.
My opinion
Plenty of anecdata of people who stopped eating certain categories of food and certain conditions they had for a long time went away. In my son's case, a severe case of eczema that persisted for years went away in a matter of weeks after we significantly reduced the amount of hydrogenated oil products available to him to eat.
Sure enough, when we would visit my mom's place which had it, and he'd indulge, the symptoms came back. Same thing when we would buy it at home and he's splurge, he'd have the same problems recur. Cutting it out of the diet is the only thing that correlated highly with the absence of the condition. This happened even after a move from one state to another.
One case, not proof, but definitely repeatable in our circumstances. I have heard a LOT of similar stories. Is it proof? No, but it's an amazingly easy thing to try. It's takes an adjustment, but it intuitively makes sense. Processed food of today is something our ancestors wouldn't even recognize as food. It's just not what our bodies were designed to handle. Some can handle it better than others, but such a processed food and artificial sugar-heavy diet can't be called natural or even healthy.
And the meat they did eat was lean game meat. It was high in unsaturated fats - like our modern day oils. Not like a steak. A steak is a product of farming. It’s a new invention, <10,000 years. Prior, humans ate almost exclusively nuts, fruits and foliage.
Yes oils are “refined”, but humans have been eating unsaturated oils predominantly for almost all of our existence. The proliferation of animal fats is very, very new. Really, it’s past 100 years. Before that meat was rare, it was a delicacy, very expensive for people.
Now, high sugar is a different story. But the oil thing is complex, it’s not as a simple as oil bad animal fat good and natural. No, it’s very unnatural.
Meat only became more of a luxury in the agricultural age where we started squeezing more and more people into smaller and smaller regions which meant there was no longer enough to go around. So plebs got the carbs, and royalty got the protein. FWIW you can also see this in the groups that have ancient traditions dating back far into the past, like the various tribal groups in Russia, Mongolian nomads, etc. Meat, and many highly creative ways of preserving it [1], remain the majority of their diet. They probably don't date back to the paleo, but at least far back enough to falsify the claim that animal fats are even remotely novel.
[1] - https://www.rbth.com/russian-kitchen/334150-dish-kill-kopalk...
In reality we have little to no idea what the proportion of meat to non meat humans ate at the time.
More realistically, different groups of humans ate different ratios of such foods.
There were almost certainly a pretty large group of humans, for example, who were basically frugivores.
You can simply look up Wikipedia and find all the references about our limited knowledge and the high likelihood that there was no single paleo diet.
https://en.wikipedia.org/wiki/Paleolithic
Ultimately, humans have been opportunistic omnivores capable of eating and surviving on whatever was most easily available, which is part of why they spread so successfully across the globe.
Trying to look at our history is a silly way to determine what is a good diet for humans today when we can scientifically examine humans today and identify what foods are healthier than others for them.
It’s like instead of noticing that drinking purified water has better outcomes for human beings today, insisting that we shouldn’t live drink untreated water straight out of streams and lakes because that’s what our Paleolithic ancestors did.
The idea that paleolithic humans, in any significant number, may have been 'frugivores' - living off fruit, is based on a fringe book for which I was able to dig up very little other than a somewhat scathing review here, [1] concluding: "If there is any science that is influenced by our cultural background, expectations, and desires it is anthropology, and we must take care to make sure that what we want to be true doesn't obscure our vision."
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As for just 'sciencing' food, it doesn't really work because health is more holistic than basic measurables. Your example hits on one aspect of this. The motivation for 'real water' is because we've relatively recently learned that the human gut biome has a dramatic influence on our health and psychology. It even has a potential link to autism. I'm not ready to start going for 'real water' to address that but there are related issues.
For instance glyphosate was believed to be safe because it having no apparent reaction on the human body, but it turns out that (amongst other issues) it completely wrecks the human gut biome with effects that are not well understood. Yet if you look at the nutritional content or other measurables of e.g. glyphosate desiccated wheat, there's not going to be any red flags outside high levels of glyphosate. It's even a viable explanation for the odd rise of seemingly inconsistent 'gluten sensitivity'.
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Anyhow, point of that all being that we know what worked in the past, worked and worked extremely well. The dramatic rise of various issues in the present ranging from declining IQs, increasing obesity, falling testosterone levels, sharp increases in many forms of mental illness - autism not least of all, and so on - suggests that we're doing something, or more likely - some things, that are quite harmful to ourselves, but that we probably believe to be safe.
[1] - https://www.wired.com/2009/06/book-review-man-the-hunted/
Several hundred years is certainly possible, Medieval cemeteries can be analyzed like that.
(Whenever my dentist cleans my calculus, we joke that we are ruining some future archeologist's work :)
Population in specific places used to eat meat because nothing grows there, but they were an exception to the rule. It's been known that our ancestors were mostly scavengers.
Hunting animals is much more dangerous that picking strawberry, back then a cut may lead to death, a broken bone was death.
The Maasai are also known to eat a lot of meat and dairy.
But, humans have been eating unsaturated fat from nuts, seeds, and meat for millennia. Unsaturated fat is not the devil. We have very strong evidence that a diet high in meat, particularly farmed red meat, is both carcinogenic and causes heart disease. When you look at high processed diets across the globe today, you'll notice they have similarities:
1. Extreme consumption of fatty, farmed meats
2. Very little fruits, vegetables, nuts, and other foods high in fiber
3. Processed shelf-stable goods
4. Extreme portion sizes
When people look at the Mediterranean diet, it's not just that they eat much more food high in unsaturated fat as opposed to saturated fat. They also eat less and move much more.
Incorrect, your points are otherwise true. Inuit diet was close to 100% animal products, way more than anyone but carnivore diet people today eat.
Most Americans are obese, so we’re already eating way more than the intuit. Probably 1000+ calories more a day.
And then, Americans eat multiple servings of meat with every meal.
I agree that the fact that this meat and fat is wild may be the root cause of the differences between their and our health outcomes. That indicates, though, that we may have something in our forms of meat and dairy that potentially harms us - and that if we identify what, we may be able to get rid of that specific problem.
It's been pretty much accepted that out ancestors (a long time ago) were scavengers, then became farmers/Livestock farmers and then industrialization.
It's only with the latest that we did start to produce meat in large quantity.
Also, simply cutting out junk food will absolutely not reverse fatty liver. You need to eat less and lose weight.
However I wanted to try to get it under control myself ( cutting out almost all carbs, liver friendly diet, lot's of exercise ), she didn't think it would make a difference but she humored me and gave me a 3 month period to try and get it back to normal.
This year ( about 2 years since I started and about 1 3/4 years since my values were good ) she told me that she now has to completely remove prediabetis from my diagnosis because she can no longer justify it based on all the tests we did since then.