Designing a good 64-bit ISA, much better than RISC-V, is easy.
There are thousands of people who could design such an ISA in a couple of weeks, without any AI assistance.
The hard part, which has always been the moat of RISC-V, is writing all the required support software for a new ISA, i.e. all the utilities from binutils (assembler, static linker, ELF/DWARF utilities), compiler backends at least for gcc and llvm, debugger (at least a port for gdb server), dynamic linker and standard C library, possibly some parts of the standard libraries for other programming languages.
Previously this could have taken years and it is the only reason that has always justified the choice of RISC-V for minimum cost, despite how bad the ISA is.
If today the porting of all these software support applications to a new ISA could be accelerated with AI assistance from a couple of years to a couple of months, that would certainly enable the design and use of custom ISAs, and RISC-V would lose its appeal.