I like the optimism in this, and the rightful identification of many important bottlenecks.

It's important to recognize that many of the remaining medical problems are very hard to solve. And while I'm still hopeful for relatively simple answers to some, successful interventions for others often require changes across multiple systems, and at economic or social costs we haven't been willing to bear. Identifying new technical solutions across all stages of research is important. But we also struggle to implement many basic interventions that already work.