I mean, they're mostly stimulants, which definitely lose effectiveness over time. It would be really weird if they didn't as that's basically how our bodies work in general.
Note: I have been prescribed said medication, but have not started taking them yet so I might be entirely wrong in the practicalities (and how would one disentangle the psychological impact of medication from the physiological impact?).
I'm not sure how one would even measure this. Like, back in the halcyon days of my youth I took a bunch of stimulants, and experentially there was definitely less impact over time (habituation is a thing).
And given that ADHD is predominantly a psychological issue, then the only measure that matters is that of the patients themselves.
Do you have some of the sources you mentioned available, I'd be interested to understand the details?
That's magnesium deficiency. Promise.
(Or side effects from getting worse sleep.)
I find that incredibly hard to believe (although my doctor did mention that magnesium supplements were worth taking).
Can you point me to some research that support this claim please?
You'd probably need a few different measures of attention/executive function and you'd need to counterbalance them across people to prevent habituation.
Given that the regulatory bodies don't require studies like this, it's unlikely to ever happen.