The board runs ZMK, which handles layers quite similarly to QMK/VIA. Whether you can bind dedicated layers to output profiles for automated switching in ZMK I do not know, but toggling between layers manually via some shortcut when you switch between devices works for sure.

There is a video by one of the ZMK team members where he tested ZMK latency (wired and wireless) against other options on the market - it is, however, fairly dated: https://www.youtube.com/watch?v=jWL4nU-vtWs

The USB port allows for wired operation while charging. The fact that some products refuse to do this still bothers me (cough MX Master 3).