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One of built-in, often used by me hotkey is Ctrl-Shift-Alt-Insert (open a new temporary scratch file). It's a default one and I don't want to set up it on every new device. Another one is Alt-Shift-Insert (rectangular selection).

A problem is that it's hard to remap, because everything else I can think of is taken already.

It's also very convenient to not have to remember a bunch of extra combos or perform the gymnastics to press them, especially if you need other modifiers too like shift+pgup, shift+ctrl+pageup, etc

you can do it using any button you like. lots of keyboards are entirely remappable. i don't understand how/why one saying they never touch these buttons is some kind of flex, like it's somehow superior to avoid using some keys or something.