you can do it using any button you like. lots of keyboards are entirely remappable. i don't understand how/why one saying they never touch these buttons is some kind of flex, like it's somehow superior to avoid using some keys or something.

It's also very convenient to not have to remember a bunch of extra combos or perform the gymnastics to press them, especially if you need other modifiers too like shift+pgup, shift+ctrl+pageup, etc

One of built-in, often used by me hotkey is Ctrl-Shift-Alt-Insert (open a new temporary scratch file). It's a default one and I don't want to set up it on every new device. Another one is Alt-Shift-Insert (rectangular selection).

A problem is that it's hard to remap, because everything else I can think of is taken already.