How many users does a web 2.0 site need to take off?
nytimes.com
nytimes.com
Also, many sites, especially ones that spread virally (social networking, some dating, and basically anything that revolves around interaction with others instead of just "tools") there is an uphill battle to get the first decent size batch of users. I think linkedin is a good example of this. It took a while for them to get enough users to make it worthwhile for most professionals (those outside the valley) to want to join it.