I can more easily relate to music production which i have passing experience with. The analog would be : if you plug your guitar directly in a preamplified audio card, you'll get the cleanest possible signal, right ? Then you'd just have to post-process it through a virtual cabinet and a bunch of effects to get exactly the sound you want. Except in most cases you'll get better results by plugging a guitar on an amplifier and putting that amp in a room with a microphone pointing to it. All that hardware will natively give you a better sound than you could achieve with reasonable effort on a fully digital workflow. Not better quality (in fact you're probably losing definition on that signal at several points in the chain), but qualities that on average will make the sound more pleasing to the ear. You can still manipulate the sound with virtual effects all you want, it will still retain the "grain" of the original setup.