- Column definitions aren't able to be changed with something like `alter column` after creation. To change a column definition you have to manually update the underlying schema using the `writable_schema` pragma. If you mess this up you can be left with a corrupt database.
- Column types are pretty limited. This isn't too much of an issue in practice since you can handle this somewhat in application code, but it can still be a bit annoying at times.
- You have limited options for dealing with schema migrations. You basically either copy the migrations to the server and run it there (manually or with something like Ansible), or you run the migrations in your application on startup. Ideally you'd perform your schema migrations separately from your application, and having to somehow copy/get the migrations to your server to then run the migration is a bit clunky.
All 3 of these are handled in a more powerful (and not local-only) database, and so I don't get why someone would choose SQLite except for prototyping (or places like the browser or phone apps) where performance concerns aren't really relevant.