I feel otherwise: usernames and other identifiers (URLs particularly, and a number of other widely used identifiers), should be drawn from well-known, common, and small charactersets. The original 7-bit ASCII characterset (128 distinct characters), or some subset of that (e.g., Roman alphabet, Arabic numerals) may not be the native representation of all cultures, but it is all but certainly a familiar representation, and avoids numerous homoglyphic attacks.
<https://en.wikipedia.org/wiki/IDN_homograph_attack>
By contrast, Unicode has something on the order of 160,000 distinct characters.
<https://en.wikipedia.org/wiki/Unicode>
This greatly exceeds the typical vocabulary (distinct known words) of most native-language speakers, estimated at between 20k -- 35k words for a typical adult English speaker.
<https://wordcounter.io/blog/how-many-words-does-the-average-...>