1. From my own experience, most people who use a ZIL for faster sync writes are wasting space. You only need five seconds of peak throughput (for a 10Gb connection that's ~5 GB). Create a pair of 25 GB partitions for the ZIL rather than dedicating entire devices.
2. With the remaining space set up a mirrored Special VDEV with heavy use of small blocks. 32k block sizes will still give some room for compression which, other than saving space, can increase throughput and reduce IO/ps.
3. Pause scrubs (`zpool scrub -p`) when the workload is either expected to be heavy or is actually heavy based on moving averages and resume when its safe. Even my 24 TB NAS takes 24+ hours with no other activity.