I have been writing frontends since early 2000. So I have seen it all, from activex being shinny to jquery, mootools, backbonejs, angular 1.0, php, Java Spring, Go. I looked into htmx and it is very much a second attempt at angular 1.0, which I did use for some good half decade as that was the best option at the time, but sooner or later, you get sick of stuffing "little codelets" inside attributes all over the place, which is exactly what htmx does.
If you want to understand what htmx is going to look like at scale, look at angular 1.0 projects.