Cyan shipped at least one Hypercard game, before Myst.
Myst ran in Hypercard in early Mac releases but switched to a cross-platform runtime Broderbund built to sell Myst on Windows CDs (and consoles and more).
Riven was also majority designed/prototyped in Hypercard as a development platform, but more directly targeted from the beginning that same runtime Broderbund built for running Myst cross-platform.