The biggest issue was always cost. But there's still an alignment problem. Without human supervision, things might drift away from the original specification and intent.
From my own experience, what works best is some kind of Hoare/separation logic (contracts), as these are quite easy to follow and decompose.
Even something as simple as a minimal Haskell subset, plus a bit of LiquidHaskell, can get you really far if you are pragmatic.