Does anybody think that evolution just stops? A species only stops evolving when it is wiped out.
I'm also not sure where the line between selective breeding and "evolution" , I wouldn't consider a Pomeranian an "evolution" of a wolf (though I guess it is a different species). Is any persistent genetic change "evolution"?
As for humans in general we've effectively eliminated most sources of selection, survivability really isn't an issue anymore, and fecundity is largely random, pretty much anyone can have kids, or choose not to have kids. The strongest thing we're probably selecting for right now is Mormonism and even they aren't making a dent in evolution.
Evolution isn't magical, it's purely probabilistic. You can drive the probabilities down real low and then genetically engineer the rest away.
In practical terms it would be impossible to genetically engineer away genetic variation (assuming you could convince people to stop having sex and visit your cloning lab instead). There are all sorts of things like DNA damage, horizontal gene transfer, and just the inherent error potential of reproduction that you would never be able to eliminate.
Of course it would also be highly undesirable to stop genetic variation, since that's what gives a species the ability to adapt and survive.
Anyone can reproduce and pass down their genes, so what mutations are we currently selecting? Maybe looks, but I doubt even that.
So, at best, the argument seems to be that the surviving gene pool may get more complex with lots of optional mutations which all coexist? Could we end up like some plant species full of cultivars where larger swathes of genes are expressing differently out of a very convoluted library?
If you're envisioning medical science to allow people to survive with otherwise lethal mutations, I would say that is not an escape from evolution. Instead, you've revised the reproductive cycle to include more epigenetic components. The species is still the survivable set of genes and cultural practices which are evolving together, and which terminate when they no longer function as a system.
Yes, ability to fend off (or avoid) a tiger attack is not much of a factor nowadays, but even something as simple as a religion that encourages having large families, and encourages marrying within religion (you don't need to live on an island to be somewhat genetically isolated) will have an effect.
As far as survival (not dying) goes, I'm guessing that risk appetite, and certain specific forms of it (e.g. fear of heights) has a genetic component, and it looks like base jumpers and free soloists are experiencing selection pressure!
In the modern world there is also a lot of truth to the premise of the nominally satirical movie "idiocracy", where it's not things we regard as positive (strength, intelligence, etc) that drive reproductive success, but in fact the opposite, with birth rates among the unintelligent often higher than that among the intelligent (who are prone to worrying about having kids).
What tends to drive evolution the most seems to be occasional rapid shifts in the environment rather than stable selection pressures. For example, we were lucky that COVID-19 wasn't worse than it was, but nonetheless by definition those who died were those with immune systems less well prepared for the new threat, and the human species as a whole has now slightly "evolved" to be better able to survive that selection pressure.
Isolation (really meaning tendency not to inter-breed) doesn't have to be physical - it can be cultural too, and it seems this isn't limited to humans - many animal species that are on the cusp of speciation (lions/tigers, horses/donkeys, etc) share the same habitat and are just choosing to avoid each other.
In any case, "isolated" populations are only necessary for speciation, not for evolution. Even a single drifting gene pool is going to evolve to adapt to the changing environment, since individuals will still differ genetically. Whatever the environment throws at you will cause some individuals to do better than others (e.g. you survived the Ebola outbreak, others didn't), and these fitter genetics will then spread in the gene pool.
We have changed evolutionary pressures, but certainly not removed them.