So far in 6 months I ran into a single issue: On day 1 of the new Subnautica early access I had to do some debugging and downgrade nvidia drivers to a previous release. But this was fixed after about a week.
No other game gave any issue what so ever. I run everything on the cachy proton version. 4090, 5070 Ti, 5090. All work perfectly. DLSS, Frame gen, older titles too.
If you want to there’s convenience flags to auto upgrade things like DLSS to latest versions etc. It’s not something you have to use, but I found it really nice compared to the Windows equivalents.
I’m so beyond happy to have zero Windows left in the house. :)