Regarding the MMU, the problem was/is the OS. AmigaOS uses message passing between processes extensively, and those messages often involved passing pointers to structures that the receiver expected to be able to dereference and even writ to in some cases.
I'm on record repeatedly arguing over the years that it would be possible to retrofit at least limited memory protection onto AmigaOS, but it's decidedly not something that'd be simple to do, and most likely you'd need to basically sandbox old apps and create new API's for new apps to do it properly.
The API is already there! AllocMem(, MEMF_PUBLIC) allocates shared memory, otherwise you get private memory.
You can then enforce memory protection around that, but obviously the entire OS is still built on message-passing between tasks where the message itself remains at exactly the same (public) address and isn't copied between private memory spaces, and there's a gentlemens' agreement as to who currently owns it (PutMsg/ReplyMsg)
Software like Enforcer and MuGuardianAngel already checked this, and dinged your program for accessing non-allocated memory.
I still think it's possible but doing it to a meaningful extent would be a long tedious effort, at least for my definition of meaningful.
You have Janus-UAE which sandboxes/emulates M68k apps for AROS "rootlessly" in that it bridges a number of structures etc. That mostly solves the problem on modern hardware for legacy apps, though it's a painful solution.
Then you could aggressively upgrade message formats for "native" apps to replace pointers with opaque handles.
If done at the time you could of course had relied on more of the developers of various apps still being active and willing to update their code and might have been able to avoid the Janus-UAE approach, but there was never a point at that time where anywhere close to a majority of users had MMU's,
It's not "only" the message address space, as e.g. messages included pointers to a lot of other data structures that'd now either need to be copied or mapped into the receiving process, or the message formats reworked.
That's demonstratably false. But the A3000 was a ficker fixer.