The latest and greatest method of exploiting and monetizing the male loneliness epidemic.
Also, this completely ignores the small but not insignificant minority of male vtubers
I get the impression that a lot of the female characters are dudes.
It's also kinda misogynistic, plenty of women enjoy anime culture. Many prominent artists for vtuber models are also women (and occasionally vtubers themselves). To the level that calling the model artist "mama" and the model rigger "papa" is a common trope.