As SQLite is often used embedded, bloat matters.
So I suggest that "PRAGMA edition" to be only be a shortcut to a list of PRAGMA commands, that would be expanded at the library level: PRAGMA edition would never appear in the DB file. As such, the build of the library would just support a limited set of editions, with a removal policy in default builds. Maybe editions could even be defined at runtime (a system table?) as a way to load them dynamically if old editions are needed beyond builtin support (think about the state of SQLite in 2046).