I don't believe in any sort of anthropomorphic "god", nor do I put any stock in any particular religion or religious text. Beyond that, the phrase "something higher than myself" is pretty vague and doesn't mean much to me.
I heard a saying once that went something like "the meaning of life, is a life of meaning". My interpretation of that is that I get to choose the meaning of my own life, and that it's my responsibility to do so. Given that mindset, and my very individualistic, libertarian, almost Randian[1] viewpoint, I don't see any use for seeking any sort of "higher power" or "higher purpose". I am my own purpose, my own end, and I am sufficient.
Aaah, I was also heavily influenced by reading a lot of Existentialist[2] stuff a while back too, and I sort of see things in a "when I die, you all cease to exist" world-view. Except not quite, which is why I do care about things like helping the poor and leaving the world better off after I leave. So, yes, I am very selfish in the Randian sense, but my selfishness leads me to want a world that's more free, less conflicted, and more rewarding than the present world, even for as-yet-unborn generations. It's hard to explain why, but none of it - in my view - reduces to any sort of spiritual notion or need for any external force / influence / god / whatever you want to call it.
As to the issue of "what about comfort in the face of tragedy" or whatever, I have adopted a somewhat Stoic[3] (if not in the strictest classical sense) viewpoint as well. That seems to play well with the individualistic, existentialist mindset I have. As a wise man once said "Keep buggering on"[4].
Anyway, that's just me. YMMV. :-)
[1]: http://en.wikipedia.org/wiki/Ayn_Rand#Philosophy
[2]: http://en.wikipedia.org/wiki/Existentialism
[3]: http://en.wikipedia.org/wiki/Stoicism
[4]: http://www.winstonchurchill.org/learn/biography/biography/ch...