That applies everywhere. You’re commenting on a forum for startups that compete against established players. David will always, in the long run, win against Goliath.
Every Goliath may, in the long run, meet a David that beats it, but this premise ignores all the thousands of Davids that don't win.
If you glass the villages and salt the fields, you even win against the taliban and vietkong.
You may win tactically, but you lose strategically - firstly by demonstrating that surrender is pointless, and secondly by creating a martyr movement across the world.
When you sow fields with salt, the only harvest you should reasonably expect is more blood.