Raymond Chen has a blog post[0] about using Alpha to develop 64bit Windows before Itanium hardware was available.
Virtually Fun has some more excellent background on finding a compiler for 64bit Windows[1], finding a copy of Windows 2000 64bit for Alpha AXP[2], and a detailed article about making an ISO from the found copy.
[0] https://learn.microsoft.com/en-us/previous-versions/technet-...
[1] https://virtuallyfun.com/2023/05/05/hiding-in-plain-sight-th...
[2] https://virtuallyfun.com/2023/05/15/windows-2000-64-bit-for-...
[3] https://virtuallyfun.com/2023/06/26/axp64-2210-installation-...