I've been keeping my desktop machines running 24/7 for ~25 years. I only reboot when necessary.

I remember having around 280 days of uptime on Windows 7 when it went end of life. Having a UPS helps a lot to protect against short power outages or blips.

Nowadays I run Arch Linux, it's been 12 days since a reboot. Not trying to break records, I reboot to apply kernel updates when it's convenient. Since I use tmux and have terminal heavy workflows it takes 1 command and a few seconds to resurrect all of my sessions to get back to where I was at before.