I do still enjoy the odd >30 day uptime on my PC. Usually only reboot when a new kernel version is cut.

I used to reboot into every kernel patch but often I leave .0 running for a very long time now. They seem stable and the kernel moves fast enough nowadays there's often another .0 right around the corner. There might be exploits but they're not a valid threat model for my little desktop.

If something smaller like Mesa updates, I can reload everything simply by logging out/back in, no need for a full reboot/LUKS unlock.