The loop is "look at this file in this repo, find bugs" iterated over every file in a project, with the ability to look at the rest of the repo for cross-file bugs related to the file they're instructed to look specifically at, but yes. The Anthropic folks have basically said that's how they're doing security audits (Nicholas Carlini is an Anthropic employee and he's done talks about it), so I assume that's how Mythos found its bugs.
I've benchmarked it, and the "here's a repo, find bugs" approach finds far fewer bugs. Like, dramatically fewer. Models are good and contexts have expanded, but focus still wins with hard problems. You could probably tell the good models to make a plan to audit the repo, and it would end up making its own "loop" in the form of a checklist of files to look at over several sessions or via subagents, I assume.