The 767 2-3-2 layout is my favorite, with only 1 middle seat per row, yet still two aisles so you can use one while the other is blocked, or walk little loops if it's not.
Wife and I just flew on an A330 in a 2-4-2 economy layout. With both of the outboard seats on one side, it was not bad.
Reserve your seat then. Doesn’t cost that much on most airlines.
I always do, but, just this Saturday, due to some air-traffic meltdown (perfectly understandable considering the heat wave), we had our aircraft swapped for a slightly smaller one, and I had to renegotiate seats to be together with my kid.