The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.
What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body?
I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.
I've heard it widely described as reducing mental noise around food.
Eating healthy food alone isn't solution, you need to make your life active as well.
https://www.verywellhealth.com/glycemic-index-vs-load-521436...
Blood sugars spikes then drops can have different impacts on food appetite.
Moreover, you dont need to eat anywhere close to 5k to be morbidly obese.
1 cup of roast nuts over TDEE will gain you 100lbs in a couple short years
TDEE rises as body weight rises (heavier body burns more)
Overfeeding increases NEAT in some people (more fidgeting, movement)
In some video a woman was eating 8-10 Oranges a day just as a snack on the side.
No knowledge about sugar or calroies, just the thought "but its a fruit its health". No fruits are not healthy
Yes. Fruits are healthy. One orange is healthy. 10 oranges are unhealthy. Same concept applies to water. Drinking too much can be unhealthy as well, but that doesn't change the fact that water is good.
You made that up tho.
10 oranges have a total of roughly 700 calories and 120 grams of sugar while only having 30 grams of fiber. It's mainly sugar. Eating 10 oranges per day crowds out protein, fat and other nutrients.
It's not a made up claim. You are a made up claim, troll.
I know it ends up as pedantry, but specifying the period with every post/restatement is so critical in these threads. 10 oranges a day is unhealthy, but so is 10 oranges a year to someone trying to make a counter point.
Its an issue if you drink orange juice not when you eat it. Eating takes longer and is getting balanced from the fiber.
A diet can be healthy if it's the nutrient combination of different foods that result in certain number of calories, protein, fat, carbs, minerals and vitamins per unit of time.
Healthy in a way, but surprisingly a lot of sugar ( either added or from the fruits)
https://publications.aap.org/pediatrics/article/139/6/e20170...
>Pediatricians should support policies that seek to reduce the consumption of fruit juice and promote the consumption of whole fruit by toddlers and young children already exposed to juices.
It's a lot harder, as many of the comments mentioned, because of caloric density and lack of appetite hacks (sugar, salt).
A can of Mountain Dew is 170 kcal + 46g of sugar.
A navel orange is ~75 kcal + 13g of sugar + 3.2g of fiber + 1.25g of protein.
So take someone from Appalachia with a 4 can / day habit (modest), and that's ~10-12 oranges. That's a lot of oranges to not get sick of eating.
Which is where I think the sugar + salt difference comes in.
It's far easier to overload on the same food when it's stuffed with these appetite attractants than a caloric equivalent of healthy food, because the health food will taste more similar (read: like itself), which will eventually get boring.
if you one broccoli head with one pound of icecream then sure, you will feel hungry again quite soon
If you have a stomach and appetite that are capable of consuming the 15 to 20 lb you need to eat 3,500 to 4,000 calories of similar foods, you ought to call a research lab
1) you didnt eat the most calorie dense foods
2) you dont need crazy calories to get fat, just above your burn rate.
What part are you confused about?
Long before LLMs, there was a different but similarly misguided hype around making food more convenient. Making money off ignorance is not "innovation", but we live in a world convinced by arrogant and pretentious fearmongering liars.
As always, just do it yourself. It's not that hard after all.
Addiction-like behaviors related to food transcend not only human culture but also even other species.
Do you know what nutrients are? Deficiencies are the cause of the noise. This is an evolutionary feature, not a bug. Your body is expecting you to keep eating alternatives until you eventually stumble onto the foods that make you feel better and then keep eating those. In severe cases you might need more patience with the right foods, but if you already feel like crap and you know you just started barely eating healthier, why stop now?
This search process has been somewhat disrupted by our modern environment, but it's not like the good food isn't right there. On the other hand, you don't need trial and error anymore. There's plenty of information available. You can even go see a doctor and get a blood test to confirm both your deficiencies and everything else I just said.
Does that answer your question?
EDIT: to reply to replies below and I am "posting too fast"...
TLDR: Y'all need to see a doctor.
I used to weigh 400 lbs, had a bad enough drinking problem to cause numbness in my legs (B12 deficiency to boot), and a sky high A1C. I recovered 100% after a decade of this self abuse. Doctor didn't bat an eye back then nor when I recovered a couple of years later. They see it all the time and my "success" story is very common. Most of us understandably find this all too embarrassing to shout about online. We'd get drowned out by influencers trying to sell you crap anyway.
Also, sorry not trying to be callous, but long term deficiencies can cause permanent damage. If you're still experiencing "food noise" after a serious attempt at a planned diet (and magically never had any other symptoms warning you of the impending damage) I have some doubts, but that's a whole different topic.
Anecdotally: no, it doesn't. Maybe it did for you. I spent most of a year once on a predesigned meal plan, and the only thing it changed about the low-key but constant food noise was better knowing when I had a safe margin to indulge a little bit.
I just eat too much of it, because food tastes good and it's a source of dopamine for me. Like most people with food noise.
Also when I get up and finish eating, within 30 minutes my brain is thinking what's going to be the next meal I eat. Food noise.
Yes, some people can lose massive amounts of weight by "just eting right", my brother in law lost 20kg by just not drinking beer anymore. I haven't had a beer in 3 years and didn't lose a single kg. Food noise.
Agreed, and often the root cause is something else in a person’s life (stress, feelings of losing control etc ).
Adding new labels related to food doesn’t do anything to fix the underlying conditions and if anything distracts from them and points the blame at food and physiology, which is not often the root cause of over or under eating.
the perpetrators are the people selling poison under false auspices.
we're not blaming people with pica for eating drywall.
We're blaming profiteers for shoveling garbage into the mouth of anyone with a buck while systematically lobbying to maximize garbage advertising and minimize actual food where feasible and simultaneously incentivizing sales groups as much as is profitable -- all the while trying to convince medical professionals and scientists to produce overtly narrow results to support the public consumption through bogus 'science' papers.
Go into any western supermarket and there are massive aisles of fruit and veg, along with various types of protein.
None of these eating disorders are new. If anything it is far easier to be healthy now.
But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway.
"Food noise" is much more than just craving calories, we have cravings for most of the different nutrients we need. That is how people ate a balanced diet in history even though it was much harder to do back then, peasants craved meat and vegetables even though it was easier to just eat potatoes for calories.
I think there’s a distinct difference between what people are describing as “food noise” and a normal appetite.
I also find drinking alcohol much less pleasant. I still drink sometimes but after a few beers or glasses of wine it starts to become very unappealing and I stop.
I do bodybuilding and I’m still getting my 150g of protein in.
I’m barely overweight and I’m losing weight very slowly but I’ve decided I’m likely to stay on GLP’s long term, if not forever, just because the lifestyle changes have been so incredibly good.
Perhaps this helps dispel the myth that GLP drugs inherently = relentless starvation.
Also the late night cravings are more specific: instead of vague "need to eat something", it's "I'd love a tomato" or "mmm yogurt" or "actually a load of carbs would hit the spot".
I can link to Wikipedia too. Which part is the straw man?
Night and day, stopped always being hungry... I've tried Noom before (eating highly filling, low calorie foods, but filling, not satiating), but that only worked while I was tracking (and always forcing myself to keep it up)...
Losing weight required work on top of that, but the protein just made my hunger response start working properly again.
People talk a lot about meat, but not enough about dairy. My prayers were answered at the altars of feta, greek yogurt, half and half, butter, cottage cheese, etc. They made salads not suck. They opened up a ton of lower carb dessert options. My gut health improved. All of my health improved.
I no longer treat these humble foods as optional extras. They perfectly fill the gap in my daily protein needs. They were never unwelcome, just forgotten.
I'm not advocating for a crazy diet. I'm just saying people ignore the basics and assume that healthy food has to be miserable. Small changes add up and make a big impact.
Calorie counting diets had no restrictions on what they ate, as long as the participants didn't exceed the calorie target.
Low carb (Atkins) had no calorie restriction but had to restrict carbs.
High protein also didn't have calorie restriction but participants had to ensure at least 20% of the calories in meals were proteins.
They found that while all helped people lose weight, only the high-protein made it stick reliably.
I used that as basis for my own weight loss and it worked very well for me. As you said it made me full in a different way. YMMV.
There is also the variable that you can work out too much. I did a brutal 30 minute glycolytic conditioning session on Friday and it just doesn't matter how much protein I consume the next day. Something with ghrelin goes off the chart and the next day takes huge will power to not just eat everything.
I think it is even worse with max effort weight lifting.
Is the Modafinil used for alertness or a different off label purpose? I'm always interested in potential helpful interventions.
I use Modafinil and Amitryptiline as a rather unorthodox method for treating dysautonomia which seems to be an intrinsic precursor to ME/CFS, at least in my case where I have hEDS from a number of TNXB variants.
My overall theory is that a combination of anxiety disorders (genetic inability to ameliorate stress) pushes me into a Sympathetic state and keeps me there to the point that cytokines (or some undiscovered small molecule) are created by the immune system to knock me out of that state as a backup to other mechanisms that have stopped working. So I studied some psychopharmacology to design a drug combo that wouldn’t override the autonomic state so I could both work with my natural rhythms (using weaker ligands) and increase the magnitude of the swings so that I could spend enough time in the Parasympathetic state to obviate the need for the immune system backup. I take a lower dose of Modafinil (100mg started and stayed at this dose no apparent tolerance build) and am genetically very sensitive to caffeine so that and one coffee is enough to get me amped for the entire day, but I need amitryptiline to bring me back down to sleep (started as 25mg and many years later I’m at 125mg due to increasing tolerance). I do want to bring down my reliance on amitryptiline but I’m working crazy hours and figure I can wait to titrate down my dose later. I’ve been at this same dose for a year now so it’s at least not getting any worse).
Thanks for the information, it's such a frustrating condition with a dearth of good information and research.
Now if you search "reddit eds glp-1" or tirzepatide you'll see tons and tons of long threads of people all saying the same thing - it's the only thing that actually helps.
For me it was something of a miracle, I have two overlapping immune issues and it seems to just turn me into a much more normal, functional person. Including fixing my sleep.
Never was overweight beyond maybe ~15lbs btw when I started or took it, and the effects are 100% not because of just fasting or weight loss. I had tried keto and OMAD before, and been at healthy weight my whole life.
There's a definite auto-immune modulating mechanism and it's so strong it seems better than basically most first-class drugs. Even things like prednisone which are like nuclear weapons don't give me relief like Tirzepatide does.
Btw highly recommend Tirzepatide of the three GLP-1 drugs, for me at least it's by far the most effective and least side effects.
So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?
Pontzer’s research showed that while the Hadza were highly active, they actually demonstrated lower baselines of certain markers of metabolic and physiological stress over time compared to Western populations.
Don't quote me on this; I am paraphrasing things I remember from.
> Nonetheless, average daily energy expenditure of traditional Hadza foragers was no different than that of Westerners after controlling for body size. The metabolic cost of walking (kcal kg−1 m−1) and resting (kcal kg−1 s−1) were also similar among Hadza and Western groups. The similarity in metabolic rates across a broad range of cultures challenges current models of obesity suggesting that Western lifestyles lead to decreased energy expenditure.
> So where does the energy burn in a sedentary population come from vs highly active Hadza tribe members?
P.S.: One theory I've seen is that the extra sedentary-spend is in the immune-system, which may have both beneficial and harmful effects, depending on whether it's doing useful work versus causing problems.