I have used Blender just a bit, but it was very jarring when I first opened it and discovered that it has its own menu bar within the window, rather than at the top of the screen. It has its own save/open window rather than using the system-provided one, as nearly all truly native Mac apps do. I doubt most Mac users like this.
I have somewhat more experience with QGIS. It has a standard Mac menu bar, but the icons are inelegant and Windows-ish, window layouts are Windows-ish, dialogs don't behave correctly in Mac full screen mode. It could use a MacOS glow-up.
I think Visual Studio Code (native menu bar, native save/open, but a core UI kind of unto itself that is consistent across Mac and Windows) does a better job of balancing cross-platform vs native.
And then there's the approach taken by Adobe and Microsoft Office. These apps do a much better job of adopting native platform appearance and conventions (sometimes at the expense of application consistency across platforms).