Just about the only reason I need to reboot my Mac is whenever I watch flash video (southparkstudios.com) and forget to close it before I shut the lid down. When laptop wakes up, it's frozen and I can't kill the browser.
Buggy flash from Adobe is probably #1 reason stopping adoption of Linux right now. Not only it's slow, has numerous issues with sound, but it also crashes regularly and generally looks and feels completely fucked up: wrong font rendering, steals focus and mouse clicks form the browser, etc. Ughh..
Photoshop is the only Mac program I've seen that uses "setup" and "uninstall" paradigm, two idiocies from the Windows world.
And finally, their ridiculous Flash implementation burns my lap, I'm not kidding - whenever I visit a heavily flash-infected site, my MBP gets burning hot even for small video inserts on ESPN. BTW it also greatly reduces my battery time. Adobe software is probably the only reason why surfing the web on a 5 year old PC is a very unpleasant experience.
They are one of these old, big fat monopolies the world would be better without, but we have no choice.
Suggesting switching to GIMP isn't an argument. All our designers use Photoshop and nobody needs conversion headaches, Adobe owns the industry, it's called the vendor lock-in.