Nothing I would love more than a Ruby with a Common-Lisp like compiler and runtime. Unboxed types, native compilation, partial compilation, live image (Ruby has this but "faster Rubies" like Crystal don't), etc...
I still believe you could do pretty well there with a few basic "tricks" that could still also remain real/valid Ruby, by recognising the most common patterns, documenting them, and providing a way of marking exceptions. Combine that with freezing system classes after startup as an enabler for various optimization, and a compiler could do a pretty good job. But it's a massive piece of work to get it right for Ruby.
I'm Ruby or Lean 4.
Also I'm working on a DSL/Macros that give me more Ruby-esque quality of life things in Lisp.
As a last resort look at Racket's "Rhombus" language, it's basically an infix, Python-like syntax on top of Racket. You can use that or see how they pull it off and add Ruby constructs to it.