The benefit of JavaScript is, that, after Google really pushed it to its limit with V8 and of course NodeJS made it a backend dream, that it is ubiquitous and once written usable everywhere, much kinda like PDF.
Its versatility gave it the advantage over WebAssembly to this day, because it is not as widespread available as JavaScript.
I agree with you, that JavaScript itself is nowadays tantamount with TypeScript - what a giant leap this has been. Angular (2) was the unsung hero here. Angular was harshly criticized when they went TypeScript right from the beginning while still offering a native JavaScript version as well (which was basically unusable to be honest).
It is funny, that the last hideout not featuring TS as their default option is React, while more and more major integral projects like NextJS rely out of the box on TS. ReactJS will fall, too. It wouldn't be the first time regarding innovations coming from other projects. Again Angular is leading the innovation while ReactJS is a follower.
You rarely can go wrong with JavaScript and Python, I would say.