I have switched my full OS-level dev env to https://mise.jdx.dev/ from Homebrew+pipx+npm, initially as an experiment but found out that it actually works amazingly well. Many things get installed directly from GitHub releases or a corresponding package manager (uv, pnpm, go get ...), zero glue code to "repackage", zero version lag. You can install any arbitrary version of a package, even multiple ones at once, and dynamically adjust which ones are active per working folder or explicitly through environments.

Funnily Mise does not support dependencies, and I was quite surprised that it mostly doesn't matter, as either pnpm/uv handles that, or it's a static binary that just works. In the past, had the unfortunate experience of packaging a Python application for Homebrew (the ridiculous process involved importing around 50 dependencies as "resources", building every single one from source or manually checking if it's already on Homebrew, declaring build toolchains for 5 different programming languages as dependencies, waiting over an hour for CI to finish on every update, then an upstream update introduced a "build-time dependency loop" and the project suddenly became unpackable for Homebrew) so I totally get why Mise took the "easy way out" and just relies on language-specific package managers directly.

Only thing from my Brewfile that I couldn't replace was the Docker CLI (needed to interact with Colima). And I still use Homebrew for casks. I encourage others to experiment with their dev setups, there are some amazing new tools out there.