While I'm not that against to such a web page (when viewing it on a monitor, not a phone) I'd say follow these points:

• Don't hijack any browser functionality. Scrolling shall scroll the document, the end.

• Don't scale something to the screen size, breaking zoom! Especially don't do it so that when zooming causes a different scroll position and then it all jumps to a different slide. WTF!

• Make it accessible!

If you want to make flashy graphics and animations make a game. That is not meant as to belittle games, I love games.