The safety gates on this are extreme, and seem considerably wider than "cybersecurity and biology"; they seem to make it essentially unusable for scientists in a number of fields. I have, so far, been bumped back to Opus on 100% of my prompts.

It appears it can be tripped by things as simple as a mention of equilibrium, or anything involving something that looks like chemical kinetics, even at an abstract level. Even touching basic open source packages in my field will trigger it.

Edit: looking at the model card, it appears that chemistry in its entirety is also included in the banned topics; it's just the announcement that mentions only cybersecurity and biology. It also appears that the intent is to ban chemistry and biology entirely, rather than just banning messages deemed high risk.