#inst "1985-04-12T23:20:50.52Z" = an instant / timestamp in RFC 3339 format
#uuid "f81d4fae-7dec-11d0-a765-00a0c91e6bf6" = a GUID/UUID
More tags could be defined by the standard later, because the entire unprefixed namespace is reserved. But just having a well-defined way to represent timestamps and UUIDs is an immense win over JSON, where you have to somehow know (based on what you were expecting to receive) that this string should be parsed as a timestamp or a GUID.
Also, user-defined tags will often be used to represent a class:
#myapp/Person {:first "Fred" :last "Mertz"}
Again, no need to know (based on what you were expecting) that this particular object is an instance of Person; the data transfer format tells you what class it is. JSON has to add a field, and what field it is will vary from application to application so it's usually not possible to write a universal parser. One server might generate { "__type": "Person", "first": "Fred", "last": "Mertz } while another one does { "$$class": "Person", "first": "Fred", "last": "Mertz }, for example.
EDN also has syntax defined for sets, but that's a smaller win over JSON, because it's not often necessary to declare that something is a set. Still, there are times it's helpful; it's certainly not a bad thing to have a set syntax.
Also, EDN has comments built in to the system. Two kinds, one line-based comment (useful for actual comments, e.g. when you use EDN as a config format), and one that comments out the next thing in the file (useful for temporarily commenting out an entire section with a single token, or for removing ONE item temporarily from a list that's all on the same line so line-based comments are difficult). Because Douglas Crockford didn't envision JSON as being used for config, he forbade comments in JSON, and people have been coming up with competing proposals for putting comments back in ever since. (Thankfully, nearly all the proposals interoperate, because all of them sensibly use Javascript comment syntax, so it doesn't matter if the file is JSONC or HuJSON or JSON5, the comment syntax is the same).
But the biggest win for EDN is tags, which can convey type information outside the data structure. JSON has to use something inside the data structure to convey type information, and there's always that small chance that the name chosen (__type or $$class or whatever) will collide with a property of the actual object that was supposed to be serialized.
I also wonder if atoms can be reduced for low-bandwidth transmission. Naïvly, you could just prepend a lookup table for multiple-use atoms.
I guess it seems more like niche, additional features when GGP seemed to be claiming a big step up.
Actually, https://github.com/edn-format/edn says "It is envisioned that a reader implementation will allow clients to register handlers for specific tags. Upon encountering a tag, the reader will first read the next element (which may itself be or comprise other tagged elements), then pass the result to the corresponding handler for further interpretation, and the result of the handler will be the data value yielded by the tag + tagged element, i.e. reading a tag and tagged element yields one value. This value is the value to be returned to the program and is not further interpreted as edn data by the reader."
So if the client is specifying the handlers, then it's up to the client's handler implementation to sanitize the incoming data before instantiating the objects. And since the client supplies the list of handlers, the only tags that will be handled are ones the client was expecting. Assuming sanitizing the incoming data before instantiating objects is done correctly, I don't see any way for that to become a security issue.